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M9640613.TXT
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1996-03-04
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Document 0613
DOCN M9640613
TI Simultaneous development of two different B-cell lymphomas in a patient
with acquired immune deficiency syndrome evidenced by molecular
analysis.
DT 9604
AU Dubus P; MacGrogan G; Vital C; Martin-Negrier ML; Morlat P; Ragnaud JM;
de Mascarel A; Bloch B; Merlio JP; Department of Pathology, Centre
Hospitalo-Universitaire de; Bordeaux, Universite de Bordeaux II, France.
SO Mod Pathol. 1995 Oct;8(8):825-9. Unique Identifier : AIDSLINE
MED/96117031
AB We report a case of a man positive for the human immunodeficiency virus
who rapidly died of lymphoma with cerebral, lung, and pericardic
involvement. After autopsy, histopathological study of the different
tumor sites showed the same morphological feature of immunoblastic
lymphoma, with large areas of necrosis. In situ hybridization showed
monotypic kappa light chain mRNA within lung lymphoma cells and
monotypic lambda light chain mRNA within cerebral lymphoma cells.
Polymerase chain reaction analysis showed two different immunoglobulin
heavy chain gene rearrangements for lung and cerebral lymphoma. Here the
simultaneous association of two malignant lymphomas derived from
different B-cell clones indicates that molecular analysis of different
tumor sites can distinguish between dissemination of the same lymphoma
and simultaneous proliferation of different malignant B-cell clones.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/GENETICS/ PATHOLOGY
Adult Base Sequence Brain Neoplasms/ETIOLOGY/GENETICS/PATHOLOGY Case
Report Genotype Human Lung Neoplasms/ETIOLOGY/GENETICS/PATHOLOGY
Lymphoma, B-Cell/*ETIOLOGY/GENETICS/PATHOLOGY Male Molecular Sequence
Data Neoplasms, Multiple Primary/*ETIOLOGY/GENETICS/PATHOLOGY Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).